Time to turn Nocebo to Placebo in India

    Deepika Bhaskar

    We must widely propagate the positives of getting inoculated, underplay the negatives and whole-heartedly support the Govt’s initiatives towards massive vaccination drives

    The pandemic and its prevalence have taught us many lessons in perseverance and patience. We have raced from one decision to the next, hoping that the latest one will make everything normal again. While the scientists have been working relentlessly to understand the virus and come up with increasingly promising vaccine candidates, the virus has been playing truant and evolving in new forms to ditch human efforts and survive as more robust variants. In the wake of the ever-changing variants, efficacy statistics and reported side effects, the so-called ultimate solution to end the pandemic, the anti-Corona vaccine, doesn’t appear to be so attractive anymore. People are hesitant to take the shot, confirming the ‘Nocebo Effect’ to the perceived solution of the pandemic that doesn’t seem to be getting anywhere close to its end. The hesitancy is spread across the globe. Some think they will never get the disease while others believe the virus is on its way out. Social media has been most instrumental in spreading the hesitancy due to varied opinions of people who have wide social media presence and have contributed to turning the solution from placebo to nocebo.

    Understanding and addressing vaccine hesitancy has become very important in the drive towards normalising life, avoiding deaths and allowing the economy to run to its full capacity. These were the very reasons why a COVID-19 vaccine was needed in the first place. What made the long wait for a solution turn into vaccine hesitancy needs serious thought. As per the World Health Organisation (WHO), vaccine hesitancy is the delay in acceptance or refusal of vaccines despite their availability. Medical practitioners and scientists have been making all out efforts to discuss and address the common causes of concern. Fear and hesitancy come from the unknown, hence the awareness needs to rise. This has led to a negative mindset against the vaccine. The hesitancy has also been triggered by the side effects reported in some cases as a result of administering the vaccine. The directions to continue with the safety measures and stay with Covid-appropriate behaviour along with reporting of positive cases in some vaccinated individuals have amplified the vaccine hesitancy.

    With many cases of blood clotting reported as a side effect of the AstraZeneca jab and discontinuation of the vaccine thereafter in at least a dozen European countries before resuming them again, doubts have grown more than ever. The latest news  that Denmark has totally stopped the use of the AstraZeneca jab in its inoculation drive is not helping the cause and instilling confidence in people.

    While Governments across the globe have rolled out the vaccine and invited people to get vaccinated at the earliest, the vaccination centres report a different story. Dealing with vaccine hesitancy has become the next big challenge, even in a country like India, which is now the second-most badly hit nation in the world after the US.

    In order to build trust and confidence in the jab, a multi-pronged strategy is required with transparent communication as the key. With the second wave already in full swing and numerous variants of the original virus here, the danger is far from over. Herd immunity, as it was being perceived, is nowhere in sight as there are people who have reported a second infection. The diversity of the disease is unfathomable.

    Attitudes towards the COVID-19 vaccines have changed overtime and varied greatly. The theory of developing antibodies on being infected has also led to a decrease in the relevance of the vaccine. Infected individuals feel they have developed antibodies and are immunised against the disease, so they do not need a shot. However, the protective abilities of antibodies in sero-surveys is unknown and their effectiveness in preventing reinfection is still to be studied. The belief that the vaccine is rushed and has not been tested properly is another setback.

    That some of the scientists have been supporting this belief has also given boost to hesitancy. It is also assumed that the efficacy of the vaccine is being underplayed so that people do not become lax in observing COVID-appropriate behaviour. Another view being expressed is that the immunity after vaccination lasts for only six months, which wrongly implies that the shot is not effective. People also think that if the survival and recovery rate is 99.6 per cent, why even bother getting a jab.

    All these supposed opinions and views have stopped people from getting vaccinated. Giving compensation for getting vaccinated has always backfired as people think that they are being paid because there is something to hide. The only groups that have justifiable concerns are the elderly, people with co-morbidities, pregnant women and those with high allergic reactions to vaccines. Also, there is no vaccine to protect our children, as of now. Though getting vaccinated is a personal choice, the most successful inoculation drives have been built on knowledge exchange, accessibility and successful stories of those getting vaccinated.

    Sherita Hill Golden, vice-president, chief diversity officer and a Professor of Medicine at Johns Hopkins Medicine talks of 12 things you need to know  in the wake of  the current vaccine hesitancy. The facts and insights into making a personal choice to get inoculated include the following: Getting vaccinated can protect you from getting COVID as your body will be ready to fight the Coronavirus if you are exposed to it; the people of colour are especially vulnerable to severe COVID-19 and its risk factors; getting inoculated helps others in the community, more so when people have chronic medical conditions; more vaccinations mean a chance to return to normal after having to experience closures, cancellations and postponements; though the vaccine development was fast, no steps were skipped while testing for safety and efficacy; diversity in vaccine testing helped assess safety and effectiveness; side effects of the COVID-19 vaccine are sparse and temporary, mainly limited to a sore arm, mild fever or body aches; it is possible to get the shot despite allergies except if you have severe allergic reactions to vaccines; the vaccine is safe for breastfeeding mothers, though pregnant women should discuss it with their doctors as the vaccine have not been tested in pregnant women; the jab can give you extra protection, if you already had COVID-19; waiting too long allows the virus to spread in the community, hence, time is of the essence for the vaccine; the pandemic can only be shortened if the vaccine is well-received.

    Hence, people have been advised to do their own research from reliable sources and take an informed decision regarding getting vaccinated. Where the issue of the shortage of the vaccine in the country is concerned, the Government is doing all it can to ensure that the needs of the people are met at the earliest. While the Russian vaccine Sputnik V has been given the go ahead and will hit the market soon after short trials here, the Centre is also looking at fast approvals for vaccines from other nations that have been approved by the WHO for emergency use. It is only  a matter of time and the shortage will be a thing of the past. But the big question is will vaccine hesitancy, too, be gone soon?

    It is time to put resolve into widely propagating the positives of getting vaccinated, underplaying the sparse negatives and whole-heartedly supporting the Government’s initiatives towards massive vaccination drives so that the pandemic situation can be controlled, the economic downturn can be lifted and normalcy restored. Its time we turned this nocebo to a placebo and support humanity.

    The writer is Registrar, IIT Delhi.The views expressed are personal.